Okposo collaborated with many other artists in the gospel and soul music fields, he collaborated with popular gospel singer Marvellous Odiete on “Follow You”, has performed regularly in Africa, Europe, and North America, and curated a series of concerts called SOPP (Sammie Okposo Praise Party). His most recent album, The Statement (2018), was produced by the Grammy-winning Kevin Bond
In 1992, Okposo became a soundtrack producer in the Nigerian movie industry. This was the official start of his career as a producer. He then switched to making music.
When he released his first album, “Unconditional Love,” in 2000, with the hit single “Welu-Welu,” he shook up the music business. Okposo was known all over the world and won many awards in Nigeria
Okposo issued a public apology to his wife, Ozioma, via his Instagram page on 24 January 2022, following his infidelity. The apology came a day after a lady, known only as African Doll, accused him of impregnating and abandoning her. Okposo told his fans that he would be taking a step back from his ministry to focus on restoration and seek forgiveness. He initially deactivated his social media handles, but restored them a few days later.
Okposo died on 25 November 2022, at the age of 51.